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產品分類 > 屋塵螨過敏原 > Natural Der p 1 (NA-DP1-1)屋塵螨過敏原1

Natural Der p 1 (NA-DP1-1)屋塵螨過敏原1

產品貨號:NA-DP1-1
促銷: 8720.00
價格: 8720.00

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250ug
美國Indoor
Allergen:nDer p 1 (Dermatophagoides pteronyssinus allergen 1)

Unit:500μg

Source:D.pteronyssinus culture medium

Mol. Wt:24 kD

Purification:

From mite culture by affinity chromatography. Purity on 
silver stained SDS-PAGE >90%

Concentration:See package insert. Based on Advanced Protein Assay.
(Cytoskeleton Inc., Denver, CO)

Formulation:

Preservative-free and carrier-free in phosphate buffered saline, 
pH 7.4. Sterile filtered.
 

Storage:Store at -20oC

Notes:(1) Not tested for endotoxin.

(2) Similar nDer p 1 preparations have been used in studies to analyze the cysteine protease activity of Der p 1, for T cell proliferation studies and antibody binding.

PDB:1XKG2AS83F5V X-ray crystal structures

Product Resources:Natural Der p 1 Certificate of Analysis

Related products:LTN-DP1-1 LoTox? Natural Der p1

LTR-DP1D-1 LoTox recombinant Der p 1, deglycosyated

RP-DP1D-1 Recombinant Der p 1, deglycosylated

EL-DP1 Der p 1 ELISA 5H8/4C1

EL-DP1A Der p 1 ELISA 10B9/5H8

MA-5H8-1 5H8 anti Der p 1

MA-4C1-1 4C1 anti Der p 1, Der f 1

MA-10B9-1 10B9 anti Der p 1

BI-4C1-1 Biotinylated 4C1 anti Der p 1, Der f 1 

BI-5H8-1 Biotinylated 5H8 anti Der p 1

ST-UAS Universal Allergen Standard

For Research Use Only: Not for Diagnostic or Therapeutic Use

References:


Lombardero M, Heymann PW, Platts-Mills TAE, Fox JW, Chapman MD. Conformational stability of B cell epitopes on Group 1 and Group II Dermatophagoides spp. Allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. J Immunol 1990;144:1353-1360.

Hewitt CRA, Brown AP, Hart BJ, Pritchard DL. A major house dust mite allergen disrupts the Immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases. J Exp Med 1995;182:1537-1544.
Schultz O, Laing P, Sewell HF, Shakib F. Der p 1, a major allergen of the house dust mite, proteolytically cleaves the low affinity receptor for human IgE (CD23). Eur J Immunol 1995;25:3191-3194.
King C, Brennan S, Thompson PJ, Stewart GA. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J Immunol 1998; 161:3645-3651.
Gough L, Schultz O, Sewell HF, Shakib F. The cysteine protease activity of the major house dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody responses. J Exp Med 1999; 190:1897-1901.
Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW, Garrod DR, Cannell MD, Robinson C. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 1999; 104:123-133.
Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomés A. Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J Mol Biol, 2009;386:520-530.


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