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產品分類 > 屋塵螨過敏原 > LoTox? Natural Der p 1 (LTN-DP1-1)屋塵螨過敏原1

LoTox? Natural Der p 1 (LTN-DP1-1)屋塵螨過敏原1

產品貨號:LTN-DP1-1
促銷: 10400.00
價格: 10400.00

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250ug
美國Indoor
Allergen:nDer p 1 (Dermatophagoides pteronyssinus allergen 1)

Unit:250μg

Source:D.pteronyssinus culture medium

Mol. Wt:24 kD

Purification:

From mite culture by multi-step chromatographic purification.

Purity on silver stained SDS-PAGE >95%.

Concentration:See package insert. 

Formulation:

Preservative and carrier-free in sterile, endotoxin-free,

phosphate buffered saline, pH 7.4

Storage:Store at -20oC

Notes:A LoTox? product, Endotoxin ≤ 0.03EU/μg.

Cysteine protease activity (see product insert) RFU @ 0.25μg/ml concentration.

PDB:1XKG2AS83F5V X-ray crystal structures

Product Resources:

LoTox? Natural Der p 1 Certificate of Analysis

Allergens are provided for research and commercial use in vitro:  not for human in vivo or therapeutic use.

References:


  1. Lombardero M, Heymann PW, Platts-Mills TAE, Fox JW, Chapman MD. Conformational stability of B cell epitopes on Group 1 and Group II Dermatophagoides spp. Allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. J Immunol 1990;144:1353-1360.

  2. Hewitt CRA, Brown AP, Hart BJ, Pritchard DL. A major house dust mite allergen disrupts the Immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases. J Exp Med 1995;182:1537-1544.

  3. Schultz O, Laing P, Sewell HF, Shakib F. Der p 1, a major allergen of the house dust mite, proteolytically cleaves the low affinity receptor for human IgE (CD23). Eur J Immunol 1995;25:3191-3194.

  4. King C, Brennan S, Thompson PJ, Stewart GA. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J Immunol 1998; 161:3645-3651.

  5. Gough L, Schultz O, Sewell HF, Shakib F. The cysteine protease activity of the major house dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody responses. J Exp Med 1999; 190:1897-1901.

  6. Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW, Garrod DR, Cannell MD, Robinson C. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 1999; 104:123-133.

  7. Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomés A. Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J Mol Biol, 2009;386:520-530.


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