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產品分類 > 乳糜瀉(麩質過敏癥) > Gliadin (recombinant; deamidated)麥膠蛋白

Gliadin (recombinant; deamidated)麥膠蛋白

產品貨號:19500/19501
促銷: 0.00

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0.1mg 1mg
德國Diarect

Diseases:Celiac Disease

Celiac disease is a chronic gastrointestinal disorder most probably caused by an abnormal immune reaction to wheat gliadin and related gluten components from barley, rye and possibly oats.

The disease is characterized by flattening of the jejunal mucosa and intestinal lesions of variable severity in genetically predisposed individuals. Celiac disease does not fit the typical characteristics of an autoimmune disease; yet is associated with anti-tissue transglutaminase antibodies. Nevertheless, monitoring of gliadin antibodies is recommended in screening populations at risk for CD and other gluten-sensitive enteropathies.

Historically, serologic tests for gliadin antibodies generally lacked the accuracy required for proper diagnosis due to missing deamidated epitopes within the authentic gliadin fraction traditionally used in diagnostic test kits.

As a protein-focused biotech enterprise, DIARECT has successfully completed the recombinant protein approach by designing and producing a deamidated γ-gliadin isoform. By sequence design the epitopes correspond to the deamidated neo-epitopes, which in the natural antigen are formed by transglutaminase-mediated glutamine side chain deamidation.

Gliadin from DIARECT is produced in E. coli.

 

 

相關疾?。蝴熧|過敏癥
 麩質過敏癥又叫做乳糜瀉,是指在遺傳性的易感個體中,一種在小腸炎癥條件下導致的對攝入一定的飲食谷蛋白——麥醇溶蛋白過敏癥。該疾病的發病機制來自環境的,遺傳的和免疫的因素的相互作用的結果。對該種病人唯一的治療辦法就是終生禁止含麥醇溶蛋白食物的飲用,這樣能使腸黏液得到恢復。組織型谷氨酰胺轉移酶做為抗原可檢測出自身抗體,促使發病機制得到更好的理解并且促進了重要的血清學測試的發展。
麩質過敏癥是一種慢性胃腸道紊亂疾病,很可能是由對小麥醇溶蛋白以及大麥,黑麥和燕麥相關麩質成分引起的異常的免疫反應造成的。
 這種疾病的特點是在遺傳易感的個體中,患者的空腸黏膜變平和不同程度的腸損傷。麩質過敏癥沒有自身免疫性疾病的典型特征,但仍與抗組織轉谷氨酰胺酶抗體有關。盡管如此,仍建議監測麥膠蛋白來篩查CD和其他麩質過敏的腸病高危人群。
 在以往的檢測中,對麥膠蛋白抗體的血清學檢測缺少精確性,沒有合適的診斷方法,由于傳統診斷檢測試劑盒中使用的可信麥膠蛋白無去酰胺基的抗原表位。
作為以專注于蛋白質的生物技術企業,DIARECT通過對去酰胺基的序列設計和生產去酰胺基的γ-麥膠蛋白亞型成功地獲得了重組蛋白的新抗原表位,而在天然抗原是谷氨酰胺轉胺介導的谷氨酰胺側鏈去酰胺基形成的。

DIARECT生產的醇溶蛋白是在大腸桿菌中表達的。

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