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產品分類 > 過敏疾病檢測原料 > Natural Bla g 2 (NA-BG2-1)蟑螂過敏原2(德國小蠊)

Natural Bla g 2 (NA-BG2-1)蟑螂過敏原2(德國小蠊)

產品貨號:NA-BG2-1
促銷: 8720.00
價格: 8720.00

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250ug
美國Indoor
Allergen:Bla g 2 (Blattella germanica allergen 2)

Unit:250μg

Source:B. germanica cockroach frass

Mol. Wt:~36 kD

Purification:

Purified from cockroach extract by monoclonal antibody affinity chromatography. Purity by silver stained SDS-PAGE > 95%.

Concentration:See package insert. 

Formulation:

Preservative-free and carrier-free in phosphate buffered saline,

pH 7.4. Sterile filtered.

Storage:Store at -20oC

Notes:(1) Natural Bla g 2 purifies as a 36 kD monomer and 72 kD dimer.

PDB:1YG92NRG X-ray crystal structures

Product Resources:Natural Bla g 2 Certificate of Analysis

Allergens are provided for research and commercial use in vitro:  not for human in vivo or therapeutic use.

References:


  1. Pollart SM, Mullins DE, Vailes LD, Hayden ML, Platts-Mills TAE, Sutherland WM, Chapman MD. Identification, quantitation, and purification of cockroach allergens using monoclonal antibodies. J Allergy Clin Immunol 1991;87:511-21.

  2.  Arruda LK, Vailes LD, Mann BJ, Shannon J, Fox JW, Vedvick TS, Hayden ML, Chapman MD. Molecular Cloning of a major cockroach (Blatella germanica) allergen, Bla g 2: Sequence homology to the aspartic proteases. J Biol Chem 1995;270:19563-8.

  3.  Pomés A, Chapman MD, Vailes LD, Blundell TL, Venugopal D. Cockroach allergen Bla g 2: Structure function and implication for allergic sensitization. Amer J Resp Crit Care Med 2002;165:391-7.

  4.  Wünschmann S, Gustchina A, Chapman MD, Pomés A. Cockroach allergen Bla g 2: An unusual aspartic proteinase. J Allergy Clin Immunol 2005;116:140-5.

  5. Gustchina A, Li M, Wünschmann S, Chapman MD, Pomés A, Wodawer A. Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J Mol Biol 2005;348:433-44.

  6. Li Mi, Gusrchina A, Alexandratos J, Wlodawer A, Wünschmann S, Kepley CL, Chapman MD, Pomés A. Crystal Structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. JBC 2008, in press.


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